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KMID : 0377519830080040325
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Chung-Ang Journal of Medicine
1983 Volume.8 No. 4 p.325 ~ p.331
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Effect of Antiarrhythmic Agent on Dog Heart Sarcolemmal ATPase Activities
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Lee Chung-Soo
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Abstract
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The well-known antiarrhythmic agents have been demonstrated by various investigators to depress myocardial contractility and inhibit calcium accumulation by the microsomal and mitochondrial fractions. However, it is now becoming evident that sarcolemma also plays an important role in regulating myocardial contractility, and it is possible that the cardiodepressant action of antiarrhythmic agents may also be due to its effect on the heart sarcolemma. Also it should be mentioned that sacrolemmal Ca^++ ATPase, Mg^++ ATPase, Na^+-K^+ ATPase and adenylate cyclase are believed to be involved in the regulation of cation movement across heart sarcolemma. It was therefore decided to examine the action of antiarrhythmic agents on sarcolemmal(isolated by the hypotonic-Li Br treatment method) Na^+-K^+ ATPase and Ca^++/Mg^++ ATPase activities. Propranolol decreased dog heart sarcolemmal Na^+-K^+ ATPase activity and other agents inhibited Ca^++ ATPase, Mg^++ ATPase significantly. whatever the exact subcellular mechanisms for the negative inotropic effect of the antiarrhythmic agents may be, the results of this study indicate that these agents affect heart sarcolemma and suggest that this site of action may partly be of some significance in eliciting the cardiodepressant effect of antiarrhythmic agents.
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